An approach to common problems

Approach to the diagnosis of anemia

Approach to diagnosis of different types of anemia

- microcytic

- macrocytic

- normocytic

- hemolytic

Diagnostic blood and marrow smears

Approach to abnormal leukocyte counts

Approach to lymphadenopathy

Approach  to splenomegaly

Approach to abnormal platelet counts

Approach to abnormal Bleeding

Approach to venous thromboembolism

Approach to acute leukemia

Disease mechanisms and cell biology

Principles of Hematopoiesis

- granulopoiesis

- lymphopoiesis

- thrombopoiesis

- apoptosis

- aplastic anemia  and pancytopenia

- angiogenesis

- endothelium

- stem cells

- telomerase

- molecular biology of acute leukemia

- biology of CML

- cell cycle 

 

Specific diseases

Erythrocytes

- sickle cell disease

- iron deficiency, absorption, transport etc

- hemochromatosis

- anemia of chronic disease

 

Acute Leukemia

-acute lymphocytic leukemia (ALL)

-acute myelogenous leukemia (AML)

-acute promyelocytic leukemia (APL)

- prognostic Factors in AML

- minimal residual disease (MRD)

- multidrug resistance (MDR)

- stem cell transplantation (SCT) in AML

Lymphocytic neoplasms

-chronic lymphocytic leukemia (CLL)

-Hodgkin's disease

-non-Hodgkin lymphoma (NHL)

-follicular cell lymphoma (FCL)

-introduction to peripheral T-cell lymphoma (PTCL)

-multiple myeloma

-amyloidosis

Indolent stem cell neoplasms

- chronic myelogenous leukemia (CML)

- inatinib mesylate (targeted Rx for CML

- myeloproliferative disorders (MPD)

- polycythemia rubra vera (PRV)

- essential thrombocytosis (ET)

- myelofibrosis with myeloid metaplasia (MMM)

- myelodysplastic syndromes (MDS)

Hemostatic disorders

-Thrombocytopenia

- Von Willebrand's disease

-Thrombophilia

-Anti-phospholipid antibody syndrome

- Heparin induced thrombocytopenia (HIT)

-Thrombotic thrombocytopenic purpura (TTP)

 

Targeted Therapy

- targeted therapy of CML

- imatinib mesylate

-antisense oligonucleotides  (anti BCL-2)

- thalidomide and Lenalidomide

- rituximab (anti CD20)

- targeted therapy of AML

- epigenetic therapies

- vascular endothelial growth factor (VEGF)

 

CASE STUDIES

- microcytic anemia in a marathon runner

- anemia in a patient with a chronic disease (ACD)

- anemia in a greek woman

- unexplained macrocytosis

- fatigue and bruising in a mechanic

- pancytopenia post influenza

- ALL in a male aged 3 in 1966

- AML: 5 case studies

- APL in a Jehovah's witness

- Hodgkin's disease in a young boy

- Peripheral T - cell lymphoma- 5 cases

- Fatigue and bruising in an auto mechanic

- Vignettes- complications of polycythemia vera

- Polycythemia and ascites

Future Directions on Malignant Disease

- Cancer genomics

- Proteins

- Proteomics

- MicroRNAs

 

 

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